Cancer is one of the main causes of death worldwide. To date, and despite the advances in conventional treatment options, therapy in cancer is still far from optimal due to the non-specific systemic biodistribution of antitumor agents. The inadequate drug concentrations at the tumor site led to an increased incidence of multiple drug resistance and the appearance of many severe undesirable side effects. Nanotechnology, through the development of nanoscale-based pharmaceuticals, has emerged to provide new and innovative drugs to overcome these limitations. In this review, we provide an overview of the approved nanomedicine for cancer treatment and the rationale behind their designs and applications. We also highlight the new approaches that are currently under investigation and the perspectives and challenges for nanopharmaceuticals, focusing on the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments.

In the future energy development of the planet, renewable energies are decisive, because of the benefits that these entail in their use, besides being inexhaustible; These are used in different ways, in heating in electrical energy, electrochemistry, among others. These energy sources in its implementation have had a social impact by generating jobs, improving the quality of life in remote areas, improving health by reducing pollution; In addition to the levels of knowledge reached not only by professionals but also the population in general. In Ecuador, during the last 10 years, in the introduction of renewable energies, fundamentally hydraulic projects have been worked on. Which four are already in operation, this is how the country has been consolidated, being one of the most energy-rich in the region, in the same way, this has generated sources of work for many people; besides avoiding large pollution to the atmosphere. In the province of Loja, a wind farm, photovoltaic power plants are deployed, and public lighting with photovoltaic systems is used in some sectors of the City. The objective of the work is to demonstrate the social impact that the introduction of these technologies has had in the province of Loja, not only in the social sphere but also cultural, economic, environmental and tourist.

Among the measures imposed by different countries, suggested by experts and epidemiologists to curb the number of infections and death from the pandemic COVID-19 is quarantined, forcing families to stay home longer and interact with family members. Life as a couple becomes increasingly difficult to lead, there are problems of gender violence since before confinement. The situation of social isolation in many cases can worsen relationships and increase conflicts, fighting, and altercations between couples, becoming a social problem. The objective of this work is to analyze the figures and reports of cases of gender violence during the 1940s. The methodology applied was bibliographic research considering reliable and current sources; from qualitative-quantitative approaches that allow evaluating the information and making statistics for a better explanation of the study. The development of the text has a deductive and an inductive approach for its understanding. The results offer a clear overview of the problem that is exacerbated in times of compulsory quarantine in families while protecting themselves from the coronavirus from home, death can lurk in domestic violence that is understood to be the safest. It concludes with an increase in the problems during the quarantine.

Renewable sources are closely linked to the natural conditions of each region and locality, their availability is very varied from one site to another, being important the evaluation of the potential of these resources, in order to determine their best use under economically advantageous conditions. These constitute the equivalent fuel for the operation of the technologies that exploit them, their quantity and quality; It also depends on the energy performance and reliability of the technology systems that employ them. An analysis of the importance of the determination of the regionalization of the RES is presented, showing the energy, economic and environmental impacts that can be estimated in specific regions and localities. For this, the studies carried out in the province of La Habana and in the municipality of San Luis in the province of Santiago de Cuba are presented as practical examples of a territorial planning, considering the conditions of each locality. The results are shown using the Geographic Information System (GIS). The contribution obtained allows the preliminary knowledge of the renewable potential (solar, wind, water and biomass), which can be considered for a regionalization of the planning with renewable energy sources, in order to reach the goals of sustainable development, based on the search Of energy solutions at the Community level.

The use of biomass for cooking food in the rural sector of the province of Manabí is very common. The present work analyzes the situation of families that use wood stoves for the cooking of food in the community of Casas Viejas, canton Jipipapa, province of Manabí. Thermography techniques have used to measure the level of emissivity to which users of traditional kitchens are exposed. It was determined that the exposure is direct and reaches temperatures up to 250 ° C, being able to raise its body temperature in the abdominal area up to 80 ° C. This periodic and prolonged exposure to thermal radiation can seriously affect the health of users.