Malaria remains a health problem in Indonesia including in East Nusa Tenggara (ENT) Province where its incidence is high. Weoe Public Health Center located in Malaka District, ENT Province has an important role as the front-line in the malaria control. The high number of malaria cases in this area may induce an economic burden due to unproductiveness at workplaces even death. This study aimed to overview the distribution and clinical characteristics of malaria patients in Weoe Public Public Health Center, Malaka District. This was a descriptive cross sectional study with saturated sampling method using secondary data of patient's medical record from January-December 2019. Malaria patients treated at the Weoe Public Health Center from eight villages were selected in this study. The data of the time of ill, patient's residence, gender, age, complaints, temperature, type of malaria, therapy, treatment results, and follow up blood smear tests result were collected. Among 815 patients suspected malaria, 198 (24.3%) were confirmed malaria positive caused by Plasmodium falciparum (41.4%) and P. vivax (58.6%). The highest cases occurred in February which reached 36.4% of the total cases. The highest incidence of malaria was found in Weoe Village (2.33%), dominated by male patients (57.6%), and mostly occurred at age 6-12 years (29.3%). Patients presented with fever (100%) followed by nonclassical malaria complaints such as nausea and vomiting (46%), headache (33%), chills (30.8%), and flu symptoms (14.1%). All malaria patients were treated with combination of dihydroartemisinin-piperaquine (DHP) and primaquine (PQ) with a 100% cure rate and follow up blood smear test are negative from malaria parasite. ABSTRAKMalaria masih menjadi masalah kesehatan di Indonesia termasuk di Provinsi Nusa Tenggara Timur (NTT), daerah dengan insiden malari tinggi. Puskesmas Weoe, Kabupaten Malaka, NTT berperan penting sebagai sebagai garda terdepan dalam pengendalian malaria. Tingginya kasus malaria di wilayah tersebut dapat menyebabkan beban ekonomi akibat penurunan produktivitas bahkan kematian. Penelitian ini bertujuan melihat gambaran distribusi dan karakteristik klinik pasien malaria di Puskesamas Weoe, Kabupaten Malaka. Penelitian ini merupakan penelitian diskriptif potong lintang dengan metode sampling jenuh menggunakan data sekunder rekam medis pasien malaria mulai Januari-Desember 2019. Pasien malaria yang diobati di Puskesmas Weoe dari delapan desa wilayah kerja Puskesmas diambil dalam penelitian ini. Data waktu pemeriksaan, tempat tinggal pasien, jenis kelamin, usia, keluhan, suhu, jenis malaria, terapi, hasil pengobatan, dan hasil tes apusan darah lanjutan dikoleksi. Di antara 815 pasien yang dicurigai malaria, 198 (24,3%) terkonfirmasi positif malaria disebabkan Plasmodium falciparum (41,4%) dan P. vivax (58,6%). Kejadian tertinggi terjadi di bulan Februari yakni mencapai 36,4% dari total kasus. Insidensi malaria tertinggi terdapat di Desa Weoe (2,33%), didominasi oleh pasien pria (57,6%), dan dengan kisaran usia 6-12 tahun (29...