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Ambient ionization mass spectrometry has become one of the most promising approaches for rapid and high-throughput screening of small molecules in complex biological matrices for emergency medicine, forensics, and food and agriculture applications. The simple procedures for sample collection and ionization without additional pretreatment are vital in these fields. Many efforts have been devoted to modifying various ambient ionization techniques to simplify the procedures and improve the robustness and sensitivity of the methods. Here, we demonstrate the implementation of rigid spherical sampler probes to improve the robustness of touch spray ionization mass spectrometry. The sphericity of the probes increases the stability of the cone-jet mode of electrospray, reduces the requirements for fine positioning of a sampler in the ion source, and decreases the possibility of corona discharge occurrence. The utilization of spherical sampler probes allows fast, non-invasive sampling, followed by rapid analysis for various drugs of different chemical classes in complex biological matrices, such as the whole blood or sebum collected from the skin surface. The linearity of the analytical signal response from drug concentration confirms the possibility of creating a simple semiquantitative method for small molecules monitoring using spherical sampler probes.

International audienceA new member of the polyporphine series-cobalt polyporphine of type I (pCoP-I)-was prepared from the starting magnesium polyporphine of type I (pMgP-I) by ion exchange, i.e. by sequential processing of the pMgP-I polymer film on the electrode surface with solutions of trifluoroacetic acid (forming metalfree polyporphine of type I, pH(2)P-I) and cobalt(II) acetate in organic solvents. The completeness of each stage of ion exchange can be judged from the change in the electrochemical and spectral characteristics of the obtained polymer films of unsubstituted porphine (?H2P-I) and cobalt porphine (pCoP-I) of type I. Oxidative transformation of this polyporphine pCoP-I was performed, which led to the formation of additional bonds between the neighboring porphine units in the polymer film (transition of polymer of type I into polymer of type II, pCoP-II). The behavior of the polymer films of cobalt polyporphine of types I and II in oxygen electroreduction was studied. The films showed catalytic activity in this process