COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to see if these factors contribute to the severity dichotomy. Children’s non-specific immune profile is dominated by naive lymphocytes and HLA-DRhighCX3CR1low dendritic cells; meanwhile, children show strong specific antibody and T cell responses for viral structural proteins, with their T cell responses differing from adults by having weaker CD8+TNF+ T cells responses to S peptide pool but stronger responses to N and M peptide pools. Finally, viral mRNA is more abundant in pediatric patients. Our data thus support a scenario in which SARS-CoV-2 infected children contribute to transmission yet are less susceptible to COVID-19 symptoms due to strong and differential responses to the virus.

Non-tuberculous mycobacteriosis, previously known as atypical, anonymous, opportunistic, or unclassified mycobacteriosis, refers to pathogenic mycobacterioses other than those caused by Mycobacterium tuberculosis and Mycobacterium leprae . These mycobacteria are known for their environmental distribution, mainly in water and soil. The incidence of non-tuberculous mycobacteriosis has been increasing in all countries and skin infections are being increasingly studied, mainly with the increase in immunosuppressive conditions and the development of new medications that affect immunological function. In the present article, a detailed narrative review of the literature is carried out to study the main non-tuberculous mycobacteriosis that cause diseases of the skin and appendages. The article also aims to present a historical context, followed by epidemiological, microbiological, and clinical characteristics of these diseases. Practical considerations about the diagnosis and treatment of non-tuberculous mycobacteriosis are detailed.

O estudo objetivou verificar a qualidade de vida do enfermeiro docente que trabalha em instituição federal, estadual e privada e comparar os resultados entre os três grupos. Os dados foram obtidos por meio do Whoqol-bref, com 26 perguntas, e aprovado pelo Comitê de Ética e Pesquisa. Foram 38 professores doutores, com exercício da docência na graduação e pós-graduação. Destes, 30 eram casados; seis, solteiros; e dois, separados, com média de idade de 46,5 anos. Quanto à qualidade de vida global, somente os professores da universidade privada têm minoria no escore "bom", mas nos domínios físico e psicológico a soma dos percentuais dos escores não apresentou diferenças relevantes, pois no primeiro foi de 47% e no segundo 43,4%; entretanto, para os domínios das relações sociais e do meio ambiente, foram 22,2% e 30,6%. Utilizar o Whoqol-bref, mesmo com amostra reduzida, forneceu informações relevantes sobre a qualidade de vida docente.

No abstract