A combinatorial model is proposed for determining the probability and information losses in an organizational and technical system (OTS) under destructive external influences. Mathematical expressions are obtained to determine the loss of information in the clusters of the control system. It is shown that the use of this model for a quantitative analysis of the probability of occurrence of events and information losses in the control system, under varying external influences on the dynamic OTS, makes it possible to carry out a quantitative analysis and synthesis of the structure of the control system that is resistant to destructive external influences. A decomposition of the probabilities of occurrence of events and the corresponding loss of information by the levels of the hierarchy of the analyzed air traffic control system is presented. The achieved result is due to the sensitivity of the model for determining information losses relative to changes in the structure of the system and destructive external influences, as well as the use of the mathematical apparatus in combinatorial analyses.