Metallic form of platinum is considered to be inert for biological reactions, but in contrast some Pt salts like hexachloroplatinate and tetrachloroplatinate, present at processes in platinum industry and at production of cytostatic platinum compounds, are among the most potent allergens and sensitizers. To assess their potential health risk, development of selective and sensitive analytical methods is inevitable. These compounds can be also found in various environmental compartments where they are released from car catalysts. However, the levels are often orders of magnitude lower which requires effective pretreatment prior to their analysis. In the present work, the most frequently methods used for the preconcentration as well as for speciation analysis of the chlorinated platinum compounds, either in occupational environment or in various natural matrices, will be presented and discussed. Abbreviations CECapillary electrophoresis CE-ICP-MS Capillary electrophoresis-inductively coupled plasma mass spectrometry HPLC High performance liquid chromatography ICP-MS Inductively coupled plasma mass spectrometry LC Liquid chromatography LC-ICP-MS Liquid chromatography-inductively coupled plasma mass spectrometry OEL Occupational exposure limit PGMs Platinum group metals

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