No abstract

No abstract

Aim: Development of allergy was studled I n relat~on to nutr~tional allergen challenge and infectious dlseases dur~ng the first 16 months of I~fe. Methods: 240 infants were allocated ether to breast-m~lk feeding during first 5 months, followed by a hypoallergenic d~et (BM), or hypoallergenic whey formula feeding (Nidlna HA, Nestle: HA).Results: In a high riik group of Infants (pos~t've family history and cord blood IgE > 0.5 kU/L) prevalence of aloplc dtsease was similarly frequent I n both nutritional groups (BM 12 %, HA 11 % at age 4 months; 32 %, 39 % at age 16 months resp ). While upper RTlequally frequent occurred i n both nutrilional groups, the HA group showed a significantly h~gher prevalence of lower RTI (EM 12 %; HA 36 %; p < 0.05). assoc~ated wth a more frequent development of respiratory allergy (29 % wiih lower RTI: 2 % w~thout lower RTI; p < 0.005) Other atopc d~seases (skin and gastro~ntest~nal symploms) occurred I n 19 %of infants wilh lower RTI and 22 % without lower RTI (n.~.). Prevalence of atoplc d~sease was also signil~cantly dilferent i n relation to gastrointest~nal infections (41 %with vs 25 % w~thout), anhough gastro~ntestinal intolerance was slm~lar in both groups (38 % vs. 40 %) Conclusion: Wh~le there was a similar allergy prevalence I n N~dlna HA fed and breast-milk led infants at r~sk, a parlcular group of lnlants exposed to gastrointestinal or lower RT infections showed a h~gher allergy prevalence I n assoclatlon with N~d~na HAleedlng and should therefore favorably be nounshed by breast-mlikVerwey', Ronald Brand2, S. Paullne Verloove-Vanharick', Jan H . Ruys', 'Dept of Pediatrics and 'Medical Statistics, Unlv. Hosp. Leiden, The Netherlands. T h e relationship between antenatally administered glucocorticoids and overall outcome at 5 years of age, applylng stepwise logistic regression analyses with 14 confounding factors, was studied. Data were collected on 1338 liveborn infants (gestational age <32 wks and/or birthweight 24 hours) there was no higher risk o n disability o r handicap at 5 years of age. In 13 chlldren whose mothers received no tocolysis o r only < 24 hours, the antenatal administration of glucocort~co~ds was associated with a significantly higher risk on disability or handicap, probably a result of confounding by indication of the treatment. 238ANTIOXIDANT...