In hospitalized older adults, a CAS-based pharmacist-physician intervention, compared to usual clinical care, resulted in significant higher number of drug cessation and dosage reductions for targeted PIMs.

Alternative splicing (AS) is a central mechanism of genetic regulation which modifies the sequence of RNA transcripts in higher eukaryotes. AS has been shown to increase both the variability and diversity of the cellular proteome by changing the composition of resulting proteins through differential choice of exons to be included in mature mRNAs. In the present study, alterations to the global RNA splicing landscape of cellular genes upon viral infection were investigated using mammalian reovirus as a model. Our study provides the first comprehensive portrait of global changes in the RNA splicing signatures that occur in eukaryotic cells following infection with a human virus. We identify 240 modified alternative splicing events upon infection which belong to transcripts frequently involved in the regulation of gene expression and RNA metabolism. Using mass spectrometry, we also confirm modifications to transcript-specific peptides resulting from AS in virus-infected cells. These findings provide additional insights into the complexity of virus-host interactions as these splice variants expand proteome diversity and function during viral infection.

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Cette étude exploratoire vise à documenter les changements qui accompagnent une intervention selon l’approche Watch, Wait, and Wonder (3W) sur le plan de l’évolution de la fonction réflexive parentale (FRP) de mères à risque. Pour ce faire, trois mères issues d’une population à risque ont été évaluées avant, pendant et après une intervention selon l’approche 3W se déroulant en quinze séances. Les changements observés chez les mères, ainsi que les résultats aux différents instruments de mesure permettent de documenter l’évolution de la FRP, mais également du stress parental et de la capacité d’empathie des mères. A la lumière des résultats obtenus, des modifications à l’approche 3W, lorsqu’elle est utilisée auprès d’une clientèle à risque, sont proposées afin de favoriser le développement de la FRP.