Detection of QT dispersion on 12 Lead surface electrocardiogram has been proved to be a strong prognostic index of malignant events and it is thought to be closely related to an heterogeneity in the repolarization wavefront.This work aims to correlate QT dispersion with the morphology of the spatial T wave loop. Indexes of planarity and geometry are derived from the 3D-ECG repolarization loop with a validated algorithm (CAVIAR).Multiple regression analysis indicates that QT dispersion measured on 12 standard lead is sign4cantly correlated with a loss ofplanarity and with a wider shape of the QT dispersion is then closely related to a spatial distortion of the cardiac vector during the repolarization phase and can be indirectly evaluated on the 3 0 electrocardiogram.loop.

We present a specifx implementation of the C A W serial analysis program which is intended to support the processing and the management of serial ECGs from pharmacological drug studies. This system includes bedside, PC-based ECG data acquisition units, computerized unary and serial ECG analysis software, and a newly designed ECG database management system which partly implements the conceptual reference model for ECG data storage developed in the SCP-ECG European project. Several system architectures have been considere4 from behide integration of the complete data processing sequence, up to networked distributed data processing, automatically performed either in real time or in batch mode. The serial ECGs are processed following the previously reported C A W method, based on an optimal comparbon of successive space-time ECG images. Emphasis is put on both ECG-related data-flow management and on the request functions which are supported.

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