Inducible vascular nitric oxide synthasc accounts for the contractile impairment observed in endotoxcmia. WC provide evidence that lipoteichoic acid (LTA) from Srupplr,&eoccrts uurees. a micro-organism without endotoxin. also induces nilric oxide synthasc. Our study demonstrates that on endothclium-free rings ofra~ aorta, LTAmlike lipopolysaccheridc inducesa loss ofcontractility restored by Mcthylene blucand p-nitro+argininc-methyl ester (LNAME). Moreover in cultured vascular smooth muscle cells. LTA produces a dose-dependent increase in intracellular cyclic GMP which is antaponired by LNAME and prevented by dcxamcthasone.

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