Gold standard: AuCl was found to be the only suitable catalyst for the 6‐endo‐dig ring closure of hydroxylated difluorinated ynones (see scheme), a class of substrates that displays low reactivity owing to the presence of the gem‐difluoro group. For the first time, a gold catalyst is used in combination with an electrophilic fluorinating reagent.

A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero‐ and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorination–cyclization with NF reagents to give cis‐ and trans‐substituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation.

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