SLN mapping can be performed easily in colorectal cancer patients, with an accuracy of more than 95%. The identification of submicroscopic lymph node metastases by this technique may have upstaged these patients (18%) from stage I/II to stage III disease, who may then benefit from further adjuvant chemotherapy.

These data confirm the efficacy of isosulfan blue and TSC for SLN mapping in colorectal tumors. No significant difference with respect to feasibility or accuracy exists between isosulfan blue and TSC. The metastatic yield is significantly higher in SLNs identified by both modalities compared with isosulfan blue only.

Transient hematopoietic aberrations are often found in association with viral hepatitis but are usually considered to be clinically insignificant. However, these changes are occasionally severe and sometimes fatal. Of the various hematologic manifestations which have been reported, agranulocytosis is very rare. Only two case reports are previously described in the literature (1, 2). We have described here two cases of viral hepatitis with agranulocytosis. The bone marrow examination in both these patients showed hypercellularity. CASE REPORTS Case One An 18-year-old whke male (C.R., WCGH 472170) was admitted to Wayne County General Hospital on October 27, 1971, because of jaundice of 2 weeks' duration. He was well until 2 weeks before the onset of jaundice, when he experienced anorexia, nausea, and progressively increasing weakness. With the onset of jaundice he also noticed pruritus. Bdth gradually increased in severity. On the night before admission, fever, profuse perspiration, sore throat, and dry cough were noticed. He admitted to heavy wine drinking which he stopped after the onset of the present illness. He denied oral or parenteral drug abuse, although he was closely associated with heroin addicts. Two of his friends were hospitalized because of hepatitis. He denied exposure to hepatotoxic drugs. Trimeprazine, 2.5 mg tablets, was prescribed by his family physician for nausea 4 weeks before hospitalization. He took only 2 or 3 tablets and discontinued the medication as he had no relief of symptoms. Physical examination disclosed a well-developed white