CTC is a diagnostic method that has been developed for more than a decade and there is a large number of studies conducted to describe its capabilities. By using new generations of CT devices and advanced software, colon analysis is possible in a relatively short time. On the other hand, high sensitivity for detecting polyps and the possibility of detecting bowel abnormalities make CTC an interesting and desirable method. The aim of this article is to determine the advantages and disadvantages of CTC, as well as its role in colon cancer screening. Compared to colonoscopy, CTC is a less invasive technique that does not require sedation. In addition to its advantages, CTC is associated with several disadvantages. A review of research proved a very small percentage of complications that can occur during the procedure, and the main limitation is ionising radiation. Despite this, it is used for numerous indications and plays a role in detection of colorectal cancer. Due to the fact that colon cancer is a major problem in the world, its frequency and mortality are trying to be reduced by screening methods. Compared to other diagnostic methods, CTC is described as a pleasant and safe examination. Considering the available data, CTC represents an ideal balance due to minimal invasiveness and high sensitivity. With the advancement of technology, CT devices and software, the role of CTC will most probably grow significantly and secure its important place in healthcare.