Marilda Casela scite author profile

Marilda Casela

4Publications

17Citation Statements Received

85Citation Statements Given

How they've been cited

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Affiliations

Hospital São Rafael, Federal University of Bahia, Hospital Ana Nery

Publications

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Rapid molecular test for tuberculosis: impact of its routine use at a referral hospital

et al. 2018

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Objective:To evaluate the impact of the use of the molecular test for Mycobacterium tuberculosis and its resistance to rifampin (Xpert MTB/RIF), under routine conditions, at a referral hospital in the Brazilian state of Bahia. Methods:This was a descriptive study using the database of the Mycobacteriology Laboratory of the Octávio Mangabeira Specialized Hospital, in the city of Salvador, and georeferencing software. We evaluated 3,877 sputum samples collected from symptomatic respiratory patients, under routine conditions, between June of 2014 and March of 2015. All of the samples were submitted to sputum smear microscopy and the Xpert MTB/RIF test. Patients were stratified by gender, age, and geolocation. Results:Among the 3,877 sputum samples evaluated, the Xpert MTB/RIF test detected M. tuberculosis in 678 (17.5%), of which 60 (8.8%) showed resistance to rifampin. The Xpert MTB/RIF test detected M. tuberculosis in 254 patients who tested negative for sputum smear microscopy, thus increasing the diagnostic power by 59.9%. Conclusions:The use of the Xpert MTB/RIF test, under routine conditions, significantly increased the detection of cases of tuberculosis among sputum smear-negative patients.

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Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+ 874 A>T polymorphism

Carneiro

Bendicho

Santos

et al. 2018

The Brazilian Journal of Infectious Diseases

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Differences in the Distribution of Peripheral Blood Leukocyte and Lymphocyte Subsets in Pulmonary Tuberculosis Patients

Carneiro

Santos

Sampaio

et al. 2015

cmbio

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Introduction: It has been suggested that individuals exposed to Mycobacterium tuberculosis can eliminate the infection through the innate immune response without the participation of the acquired immunity. However, T helper type 1 immune response is critical to control persistent infection. Objective: The purpose of this study was to evaluate the distribution of leukocyte and lymphocyte subsets in peripheral blood of individuals with pulmonary tuberculosis (TB) and positive Tuberculin Skin Test (TST). Methodology: In order to achieve that goal, we have collected blood sample from thirty-four treatment-naïve TB patients, fifty TST-positive and forty-one TST-negative individuals. Results: The evaluation has shown a significant reduction in the number of total lymphocytes, B cells, CD4+ and CD8+ T cells and percentage increase of NK cells, neutrophils and monocytes in TB patients, when compared to TSTpositive and TST-negative individuals. There was no statistical difference for leucocyte and lymphocyte subsets between TST-positive and TST-negative groups. Peripheral blood white cell counts change significantly at diagnosis. Conclusion: The quantification of these cells may support the diagnosis and monitoring of patients with pulmonary tuberculosis.

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Perfil De Sensibilidade E Adequação Do Protocolo De Antibioticoterapia Empírica Para Pacientes Com Sepse Em Um Hospital Especializado Em Trauma Do Estado Da Bahia

Boaventura

Santos

Gouveia

et al. 2022

The Brazilian Journal of Infectious Diseases

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Marilda Casela

Rapid molecular test for tuberculosis: impact of its routine use at a referral hospital

Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+ 874 A>T polymorphism

Differences in the Distribution of Peripheral Blood Leukocyte and Lymphocyte Subsets in Pulmonary Tuberculosis Patients

Perfil De Sensibilidade E Adequação Do Protocolo De Antibioticoterapia Empírica Para Pacientes Com Sepse Em Um Hospital Especializado Em Trauma Do Estado Da Bahia

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