A new series of bis-4,6-sulfonamidated 5,7-dinitrbenzofuroxans 7–11had been synthesized and tested for antimicrobial activity. The structures of new sulfanilamide derivatives were characterized by elemental analysis, IR spectroscopy, and mass spectrometry (MALDITOF). The synthesized compounds were tested for theirin vitroantimicrobial activity using the disk diffusion method against Gram-positive bacteriaStaphylococcus aureus; the Gram-negative bacteriaEscherichia coli, Pseudomonas aeruginosa, andProteus mirabilis; the fungal strainAspergillus niger; and the yeast-like pathogenic fungusCandida albicans. Our results indicate that the compounds7–11exhibit potent antimicrobial activity. The stability of the compounds was evaluated by TG and DSC methods.
Chiral S-tributylstannyl dithiophosphates and dithiophosphonates were obtained by the reactions of optically active dithiophosphoric and dithiophosphonic acids containing (S)-(-)-menthyl and (R)-(+)-menthyl substituents with gaseous ammonia and tributyl chlorostannane. The reactions of chiral ammonium dithiophosphate containing (1R)-endo-(+)-fenchyl substituent with tributyl chlorostannane or tetrachlorostannane result in corresponding S-tributylstannyl dithiophosphate or tetrakis(dithiophosphato) stannane. Molecular structure of ammonium O,O-di-(-)-menthyldithiophosphate was studied by X-ray single crystal diffraction. Bactericidal activity of S-tributylstannyl dithiophosphates was tested.
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