A brief review of the literature devoted to the rare eosin-filed granulomatous necrotizing vasculitis ChurgStrauss syndrome is given. Two clinical cases of this disease are presented from the personal practice of the authors. The complexity of diagnostics was emphasized; it contributed to the fact that the disease lasted for a long time under the guise of other nosologies which later turned out to be syndromes of vasculitis ChurgStrauss. When pulmonary infiltrates occur in patients with asthma with allergic rhinitis or rhinosinusopathy in combination with high eosinophilia of peripheral blood and neurologic symptoms, it is necessary to suspect the Churg-Strauss syndrome and conduct appropriate diagnostic measures.

56Амурский медицинский журнал №3 (19) 2017Materials and methods. To study the effect of Cytoflavin on parameters of systolic left ventricular function in acute myocardial infarction. 46 patients with standard therapy received the drug Сytoflavin (Polysan, St.Petersburg, Russia) intravenously 20 ml of the solution diluted in 250 ml 5% glucose solution, 1 times a day 30 minutes before coronary artery recanalization; 60 patients (control group) received only standard therapy. The drug's effectiveness was evaluated in terms of systolic left ventricular function: ejection fraction, end-diastolic volume, end-systolic volume.The introduction of Cytoflavin patients contributed to an increase in ejection fraction of the left ventricle of 7.9% compared to the same indicator in the patients of the control group, reduced end-diastolic and end-systolic volume of the left ventricle by 10.6% and 17.9% respectively on day 7 of hospitalization (р≤0,05). Addition to standard therapy with Cytoflavin significantly reduced the level of troponin I in patients with acute myocardial infarction on day 7 for 81% relative to the control, the activity of creatine kinase -35% (р≤0,05).The inclusion of Сytoflavin in the treatment of patients with acute myocardial infarction should be considered as pathogenetically justified clinically justified and promising.Intravenous drip for patients with acute myocardial infarction Cytoflavin 30 minutes before coronary artery recanalization on the background of standard therapy promotes the positive dynamics of systolic left ventricular function with increased ejection fraction of the left ventricle, reducing end-diastolic and end-systolic volume of the left ventricle in comparison with similar indicators of control group on day 7 of hospitalization. Inclusion in standard therapy of acute myocardial infarction succinaldehyde of the drug Cytoflavin significantly reduces the level of troponin I and activity of creatine kinase in the blood of patients with myocardial infarction on day 7 relative to the patients of the control group. Abstract. This article presents a case of successful treatment with genetic engineering biological drugs of juvenile rheumatoid arthritis. The authors draw attention to the fact that early onset of active basic treatment of juvenile rheumatoid arthritis prevents the progression of joints destruction and disability of the patient.

A brief review on respiratory damages in systemic scleroderma (SDS) is presented. The characteristic of the most frequent pathology – interstitial lung injury (ILI) is given. Pulmonary hypertension, pleural lesions, tuberculosis, secondary tumors are also described. Multispiral computed tomography in patients with SDS allows not only to identify the characteristic symptoms of ILI, but also to assess the extent of the lesion and the stage of development of the pathological process in the lungs for the timely treatment of ILI. In the two given clinical observations, lung involvement or ILI was the debut of systemic scleroderma and was ahead of other clinical symptoms of the disease; the course of alveolitis was progressive in nature, there was a significant decrease of lung volumes and an increase of fibrosis.

SUMMARY We studied the histological specimens of 62 patients who died from fibrocavernous pulmonary tuberculosis with multidrug-resistant (28 patients), poly-resistant (18 patients) and sensitive strains of mycobacteria (16 patients).A number of features have been revealed that indicate a rapid, progressive course of the destructive tuberculous process in the lungs, with the most significant morphological changes occurring in people with multiresistant forms of lesion. This process is characterized by more pronounced specific inflammatory changes in the lung tissue: the presence of granulomas with central caseous necrosis, granulomas containing Pirogov cells, long-lasting granulomas with proliferation of fibrous connective tissue around them, lymphoid cell clusters in fibrous tissue in the pericavitic zones, as well as a large the number of lymphoid cells in the granulation and fibrous layers of the cavity.

The results were analyzed according to indices of developing a burning disease, cytological examination, lipid peroxidation study and antioxidant defense (vitamin "E", ceruloplasmin), pro-inflammatory interleukins (IL-1β, IL-6, IL-8, TNF-α),) on the first and 10-th day of therapy. The degree of differences was considered to be significant when p < 0,05.Results: Due to more active processes developing in the wound earlier terms of forming marginal (7,6 ± 1,6 days) and complete epithelization of wounds (28,2 ± 3,3 days), scarring (31,3 ± 2,4 days) (p < 0,05) were determined for certain in patients of the main group in comparison with patients of the control group (10,7 ± 1,4 days, 20,9 ± 3,8 days, 29,9 ± 2,3 days, 39,7 ± 3,2 days accordingly). Duration of the temperature reaction is 11,9 ± 0,6 days and that of the painful syndrome in the main group made up 13,4 ± 0,7 days. These indices in the control group made up 16,6 ± 0,7 days and 19,9 ± 1,5 days accordingly (p < 0,05).Cellular composition of the wounds on the first day of therapy did not significantly differ in patients of both groups. In the 21-st day of therapy regenerative and regenerative -inflammatory types of cytograms were determined in patients of the main group while inflammatory and regenerative type of cytograms remained in patients of the control group.Patients with superficial burns in both groups had excessive and lingering hyperproduction of pro-inflammatory interleukins (IL-1β, IL-6, IL-8, TNF-α). Application of the proposed method furthered the decrease of their level and acceleration of reparation processes. By the 10-th day of therapy in patients of the main group having burning wounds the level of IL-1β content in the serum decreased by 45,5% ( from 132,9 [21,5; 302] to 72,4 [8,7; 127,6]), 5 [51,4; 216,7] to67,5 [13,9; 120,8], 3% (from 230,4 [123,8; 328,5] to 116,7 [69,8; 254,6]) and 8% (from 43,2 [15,04; 67] to 16,07 [6,7; 45,8]), and in the control group only -18,3%, 2,9%, 3,6%, 6,5%, accordingly.At the beginning of therapy there were not significant differences in indices of lipid peroxidation and AOD in patients of both groups. M.u. indices decreased by 46,8% and r.c. indices -by 47,9% in patients of the main group by the tenth day of treatment while m.u. indices decreased by 20,4% and r.c. indices -by 31,7% in patients of the control group. The content of AOD components increased significantly in the main group than in the control one. In patients of the main group the content of vitamin "E" increased by 39,1% and that of ceruloplasmin -by 35,4% and in the control group -by 8,7% and -by 3,6% accordingly.Conclusion. Application of HBO and antioxidant therapy with dihydroquercetin (Lavitol cosmetic", BAA "Lavitol -B").) activates the process developing in the wound that allows to improve the results of treatment of patients with superficial burns. Abstracts. International data indicate an increase in the prevalence of bronchiectasis in recent years. In connection with the expansion of computer diagnostics abilities and an increase in th...