Marino Lepore scite author profile

In this study, we sought to determine if Fischer 344 (F344) and Lewis rats showed different conditioned place preference (CPP) responses to subcutaneously administered (-)-nicotine. Lewis rats displayed a CPP response to (-)-nicotine after five pairings, whereas F344 rats showed no preference for nicotine compared to vehicle. After 10 pairings, the F344 rats showed a conditioned place aversion to (-)-nicotine, whereas the Lewis rats still displayed a significant CPP response. These results suggest that the differences in appetitiveness shown between Lewis and F344 rats to other drugs of abuse extend also to (-)-nicotine.

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(?)-nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

Horan

Smith

Gardner

et al. 1997

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A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: Effects in laboratory rat models relating to addiction

et al. 2006

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Marino Lepore

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward

Genetic differences in Δ9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains

(—)‐nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

(?)-nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: Effects in laboratory rat models relating to addiction

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