In this paper it is presented how the influence of soil-structure interaction (SSI) interferes on reinforced concrete structures in small buildings with deep foundations, with the objective of analyzing the influence of SSI on the loads and repressions, global stability and costs of materials. The analysis were based on numerical-computational simulations of a commercial building using CAD/TQS commercial software. The building was simulated with 4, 6 and 8 floors with 3 different profiles of soils, generating 8 case studies. When considering SSI, the loads and repressions did not present significant variations and the parameters of global instability were within the normative recommendations. Among the variables analyzed, the material cost of the structure was the least affected item with the SSI consideration.