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Studies have shown that hormonal, metabolic and nutritional disorders during the early phase of development and/or in the gestation may lead to transitory or permanent structural and functional changes of several organs of the offspring. Our aim was to investigate the impact of high fat diet during the gestation and lactation on biochemical parameters in the offspring of rats. High fat diet was given from day 1 of gestation until weaning of puppies. The biochemical evaluation was performed at 30, 60 and 90 days after birth from High Fat Diet dams (HFDD, n= 6) or Normal Diet dams (NDD, n= 6). Animals from HFDD group presented hyperglycemia starting from day 30 (119 ± 1.6 vs 94.03 ± 2 mg/dl, p<0.05) and LDL (45 ± 7 vs 23 ± 4 mg/dl, p<0.05). In the day 60 OHFD showed difference at TAG ( 61 ± 3 vs 51 ± 1 mg/dl, p<0.05), TC ( 98 ± 5 vs 75 ± 2 mg/dl, p<0.05), VLDL ( 13 ± 0.69 vs 10 ± 0.2 mg/dl, p<0.05) and decrease HDL (42 ± 3 vs 61.42 ± 4 mg/dl, p<0.05). These findings suggest that high fat diet during pregnancy and lactation leads dyslipidemia in adult offspring rats.Support: CNPq, Fapitec and CAPES

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Background: Fractures of the proximal humerus are challenging injuries. They have a functional impairment and can be managed by non-operative or operative methods. Surgical methods can be intramedullary nails, tension-band wiring, or plates and screws. Aim of the study: This study aims to show the outcomes of managing fractures of the proximal humerus using the trefoil plate method. Methods: Eight young patients with type 2 or 3 part proximal humerus fractures were retrospectively analyzed concerning the cloverleaf plate fixation and consolidation method. Patients with 4-part fractures were excluded. Results: We obtained 100% consolidation with a mean ROM of 109 degrees for abduction, 4.4 degrees for external rotation, and good internal rotation. Conclusion: the trefoil plate osteosynthesis method can be used in young patients with 2- or 3-part fractures of the proximal humerus.