Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. The binding energies of -8.2, - 7.6 and -7.5 kcal/mol were obtained for three analogues of curcumin respectively. Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX-2 towards the design of potent inhibitors.

Virgin coconut oil (VCO) is one of the processed products from coconuts that has high economic value. This economic value is triggered by the benefits of VCO. The people of Oma Village are located on the coast of Haruku Island which is very overgrown with coconut plants. The abundance of coconut plants has not been maximally utilized by the Oma village community. This problem prompted training to make VCO for the Oma village community, Haruku Island. This community service is carried out based on counseling and training on making VCO to the Oma Village community. Counseling was carried out to convey about VCO, the benefits of VCO and how to make VCO. The training is carried out by demonstrating/demonstrating the procedure for making VCO and providing tools and materials to partners to be able to produce VCO independently. The results of VCO products from the Oma Village community are reported to the service team and used as an indicator of the success of the VCO making training. The results obtained provide information that this product is a product that can be cultivated by the Oma village community as an opportunity to improve their economy.

Banyak kandungan senyawa kimia bermanfaat dalam makroalga yang bernilai ekonomi tinggi tetapi belum diteliti secara luas, seperti pigmen fotosintesis. Peningkatan  kebutuhan pigmen fotosintesis pada dunia industri menyebabkan pencarian sumber alternatif pigmen fotosintesis masih terus dilakukan diantaranya dari makroalga. Penelitian ini bertujuan untuk mengetahuipengaruh lama penyimpanan ekstrak kasar makroalga Ulva lactuca terhadap kestabilan pigmen fotosintesis. Tahapan penelitian meliputi, isolasi pigmen fotosintesis, pemurnian menggunakan kromatografi kolom silika, karakterisasi pigmen fotosintesis dengan KLT dan spektrofotometer UV–Vis. Hasil KLT dari ekstrak kasar Ulva lactuca menunjukkan perbedaan jumlah dan jenis pigmen fotosintesis yang mencolok antara ekstrak kasar Ulva lactuca yang lansung diekstrak dan yang dibiarkan kurang lebih 3 hari. Pada hasil kromarogram menunjukkan ada 7 fraksi pigmen fotosintesis dan memiliki warna yang sangat mencolok yang diekstrak secara langsung sedangkan ekstrak kasar yang dibiarkan kurang lebih 3 hari menunjukkan hanya 5 fraksi pigmen fotosintesis dengan warna yang pucat. Fraksinasi dengan kromatografi kolom silika gel menunjukkan adanya pigmen fotosintesis sebanyak 29 fraksi. Setelah diindentifikasi dengan spektofotometer UV–Vis ada 4 fraksi utama yaitu ß-karoten, fukoxantin, klorofil a,dan feofitin a. Lama penyimpanan terhadap ekstrak kasar Ulva lactuca mempengaruhi pigmen fotosintesis secara kualitatif dan kuantitatif.

In silico studies on interactions between the human pancreatic α-amylase (HPA) enzyme with α, β, and γ-mangostin ligands has been carried out using the molecular docking method. Ligands α, β, and γ-mangostin interact through the formation of hydrogen and van der waals bonds with residues on the enzyme active side. The α-mangostin ligands form seven hydrogen and six van der waals bonds with residues involved were Trp59, Gln63, Trp96, Thr163, Thr164, Ala198, His201, Glu233, and Asp300; β-mangostin forms five hydrogen and eight van der waals bonds with residues involved were Gln63, Trp96, Thr163, Thr164, Arg195, Asp197, His201, Glu233, Asp300, and His305; while γ-mangostin forms nine hydrogen and five van der waals bonds with residues involved were Trp59, Gln63, Trp96, Thr163, Asp197, Ala198, His201, Glu233, and Asp300. The binding afinity of α, β, and γ-mangostin to the HPA obtained were -7.0; -6.6; and -7.4 kcal/mol with RMSD value were 1,850; 1,956; and 1,811 Å, respectively. The number of hydrogen bonds that can be formed was responsible to the binding affinity. Ligand γ-mangostin has potential activity as an inhibitor of HPA enzyme due to the stable complexes formation with lower binding affinity (validated with RMSD value) when compared to α and β-mangostin.

Synthesis of new asymmetrical curcumin analogue of 1-(3,4-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one via condensation reaction between vanillinacetone and veratraldehyde in ethanol has been performed. The in vitro anti-inflammatory activities of the synthesized compounds showed excellent anti-inflammatory activity. In vitro anti-inammatory activity by using inhibition of albumin denaturation technique compared to standard dichlorofenac. Molecular docking studies were performed, where docking of the compound into 6COX active site suggested that it could exert its anti-inflammatory potential by cyclooxygenase inhibition.