SUMMARYBackground: A chronic wound is defined as an area where the skin is not intact that fails to heal within eight weeks. Such wounds usually develop on the lower limbs as a complication of diabetes, venous insufficiency, or inadequate arterial perfusion. Most of the roughly 45 000 limb amputations performed in Germany each year are necessitated by non-healing chronic wounds.

Based on this systematic review, there is no strong evidence to support one therapy over another as EBRT, BT and RP can all be considered as effective monotherapies for localised disease with EBRT also effective for post-operative management. All treatments have unique adverse events profiles. Further large, robust RCTs which report treatment-specific and treatment combination-specific outcomes in defined prostate cancer risk groups following established reporting standards are needed. These will strengthen the evidence base for newer technologies, help reinforce current consensus guidelines and establish greater standardisation across practices.

Analysis 1.4. Comparison 1 Omega-3 PUFAs versus placebo, Outcome 4 Older Americans Resources and Services-Instrumental Activities of Daily Living (OARS-IADL) change scores (12 months' follow-up, PP analysis

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