Background and Aims Tattoo prevalence has significantly increased over the last decades. Proper tattoo aftercare, such as cleansing, moisturizing, and protection against sunlight, is essential to prevent complications and to keep the beauty of the tattoo. The tolerability, performance, and cosmetic acceptability of two dexpanthenol‐containing dermo‐cosmetic products, a wash and a sun‐care, were investigated on tattooed skin in two separate trials. Methods Two single‐center, exploratory, open‐label cosmetic studies were conducted between August and November 2020 to evaluate the dexpanthenol‐containing dermo‐cosmetic products. In the first study, healthy adults applied the 2.5% dexpanthenol‐containing wash right after their tattoo session daily for 14 consecutive days. In the second study, healthy adults applied the 2.5% dexpanthenol‐containing sun‐care sun protection factor 50+ cream on existing tattoos that were daily exposed to sunlight for 28 consecutive days. Clinical examination by a dermatologist and self‐assessment through subject questionnaires were used to assess the tolerability, acceptance, ease of use, and cosmetic outcomes of both products. Additionally, transepidermal water loss and moisturization assessments were performed to evaluate skin hydration after use of the sun‐care product. Results Both study products were well tolerated, and no product related adverse events were reported during the studies. At least 90% of the study participants appreciated the performance of the dexpanthenol‐containing wash and sun‐care product, including moisturizing properties, relief of unpleasant sensations, and preservation of the cosmetic appearance of the tattoo. For the sun‐care, it was shown that its application supported maintaining the skin barrier of tattooed skin, while keeping it hydrated. Conclusion The 2.5% dexpanthenol‐containing wash and sun‐care products are well tolerated and appreciated by tattooed subjects. Hence, they represent valid options for tattoo aftercare in line with current recommendations and practice.