No abstract

Background. Sarcomas arising in the heart or the great vessels are rare entities. The prognosis of the patients is dismal.Methods. Between January 1993 and September 2006, of 1,429 patients registered to the Sarcoma Center, 14 had a primary sarcoma of the heart or large vessels.Results. Tumors were located in the left ventricle (n ‫؍‬ 3), left/right atrium (n ‫؍‬ 2/3), pulmonary artery (n ‫؍‬ 2), and ventricular septum, aorta, pericardium, and inferior vena cava (n ‫؍‬ 1 each). The most frequently encountered histologic subtypes were leiomyosarcoma and angiosarcoma. Six patients presented with distant metastases to the lungs (n ‫؍‬ 5), lymph nodes (n ‫؍‬ 2), and liver (n ‫؍‬ 1). Eight patients had localized disease. Six of them underwent resection with curative intent. Of those, two devel-

Hepatocellular carcinoma lesions exhibit characteristic but unusual apparent diffusion coefficient (ADC) changes during sorafenib therapy, consisting of early decrease in ADC after therapy onset followed by a reincrease. The ADC changes seem to reflect the underlying pathophysiologic mechanisms in tumor necrosis (most probably hemorrhagic) induced by this novel targeted agent early after therapy onset and may indicate tumor reactivation in the later follow-up period.

Imaging features of morphea are not specific and usually overlap with those of other disorders involving the skin, fascia, and musculature, such as some types of fasciitis, myositis, and so forth. Nevertheless, the imaging features of morphea reflect pathomorphologic changes of this rare disorder and enable a complete assessment of the disease extent, including depth of infiltration and disease activity.