The results of studying the effect of biferon-C containing recombinant porcine interferons -alpha and -gamma on cellular nonspecific and adaptive immunity in piglets in case of specific prevention of circovirosis and mycoplasmosis are presented. The corrective effect of the drug on cellular immunity was stated, manifested by an increase in the absorption and functional and metabolic activity of phagocytes, the relative and absolute number of T- and B-lymphocytes, T-cells with helper activity and a lower formation of the level of T-suppressors, an increase in the T-helpers/T-suppressors ratio.

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The article presents the results of studying the possibility of using integral leukocyte indices to assess the inflammatory process, endogenous intoxication and immunological reactivity in piglets with gastrointestinal infections on industrial pig breeding farms and the efficacy of therapy of sick animals with an interferon-containing drug. It was found that in sick piglets, compared with clinically healthy animals, the values of integral leukocyte indices of endogenous intoxication were higher, and the lymphocytic-granulocytic index, which characterized the severity of inflammation and the degree of intoxication associated with the infectious process, was lower. At the same time, changes in the indices of nonspecific reactivity were revealed, indicating a decrease in the activity of the monocyte-macrophage system, the adaptive capabilities of the organism and a pronounced stress reaction. The use of propig ensured the recovery of 97,5 % of sick animals. In recovered piglets, the values of integral leukocyte indices, which characterize endogenous intoxication, decreased, there were changes in the values of nonspecific reactivity indices, indicating an increase in the immune status, there was a tendency to an increase in the lymphocytic-granulocytic index, which indicated the extinction of the inflammatory process and the efficacy of treatment. The conducted studies have established the possibility of using integral leukocyte indices for an objective assessment of the presence of an inflammatory process, endogenous intoxication and the state of immunological reactivity in piglets with gastrointestinal diseases and the efficacy of therapy.