INTRODUCTIONSeizure is defined as a paroxysmal, time limited change in motor activity and/or behaviour that results from abnormal activity in the brain. Neonatal seizure is a common neurological problem in the neonatal period. Neonatal seizures have always been a topic of interest because of its universal occurrence. A varied number of conditions are capable of causing seizures in the neonatal period the highest incidence of neonatal seizures occurs during first 24 hours of life.1 Prompt diagnosis, investigations and treatment are vital as delayed recognition of a treatable cause can have a significant impact on child's subsequent neurological outcome. Results:The present study is descriptive in nature where clinical spectrum of neonatal seizures in neonates was studied. 1500 neonates were admitted in NICU during the study period, among them 200 (13.3%) developed neonatal seizures. Etiology in majority of the cases of neonatal seizures was hypoxic ischemic encephalopathy (45%) followed in frequency by intracranial haemorrhage (14%), meningitis (12%), hypoglycaemia (11%), hypocalcaemia (4%) and others (14%). The most common organism implicated in neonatal seizures was Escherichia coli (36%), followed by Klebsiella (30%), staphylococcus aureus (19%), Streptococci agalactiae (7%) and unknown (8%). Meningitis accounted for 12% of neonatal seizures. Most common biochemical abnormalities noted were hypoglycemia, hypocalcaemia and hyponatremia. Conclusions: Biochemical abnormalities may significantly contribute to seizure activity and possibly correction of these abnormalities may play a significant role in seizure control. A biochemical work up is necessary for all cases of neonatal seizures. Appropriate treatment with antibiotics is essential. Examination of cerebrospinal fluid is essential work up in cases of neonatal seizures. Neurosonogram had good potential in predicting neurological outcome in neonates with perinatal asphyxia. Neurosonogram should be incorporated in the routine evaluation of seizures.