om as , F e r na n d o G on zález Candelas, SeqCOVID-SPAIN consortium, Tanja Stadler & Richard A. NeherThis is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

Highlights The Angiotensin system has been implicated in the pathogenesis of COVID-19. Functional ACE / ACE2 polymorphisms might contribute to the outcome of COVID-19. Severe COVID-19 was associated with hypertension, male gender, and ACE-DD genotype. The ACE2 polymorphism was not associated with the disease outcome. ACE2 showed no coding variants that could explain an increased risk of COVID-19.

No abstract