A glycoprotein with multiple glycosylations can be prepared by chemical synthesis as a single glycoform. In their Communication on S. J. Danishefsky et al. describe the first total synthesis of fully glycosylated erythropoietin. Glycosylation has significantly increased the stability of the protein. The fully glycosylated native protein has demonstrated substantial erythropoietic activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.