In this paper we propose a mathematical model and an approximate equation to explain the behavior found on the photoacoustic effect generated by laser-induced nanobubbles in colloidal gold solutions. To obtain the equation, we developed a simulation program based on the widely known Rayleigh–Plesset model. A set of measurements was carried out to assess its accuracy on real samples. The equation gives a good approximation for spherical gold nanoparticles with sizes between 10 and 80 nm, and laser fluences larger than the fluence threshold for bubble formation.
Based on measuring the change of the photoacoustic (PA) signal generated by laser-induced nanobubbles, a new way to detect gold nanoparticles (GNPs) aggregation is demonstrated and applied to selective protein detection.
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