Surface-enhanced Raman spectrometry (SERS) of three sulfa drugs (sulfadiazine, sulfamerazine, and sulfamethazine) is reported. Silver colloidal dispersions prepared by simple borohydride reduction of silver nitrate are used as substrates. The capability of SERS for spectral fingerprinting of analytes with close structural properties using easily prepared substrates and relatively simple instrumentation is illustrated. By careful attention to the timing in the measurement, quantitative information can be obtained from silver colloids. Linearity was achieved up to 100 ng mL-1. Limits of detection range in the low nanograms per milliliter level.
Thanks are given to The Dow Chemical Co. for support and permission to publish this work. A portion of the work was presented on January 4, 1990, at the second annual winter conference on flow injection analysis in Orlando, FL. A patent application (U.S. 317879, March 2,1989
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