The final step for an investigation to be completed is its communication in the international scientific forum. The aim of this paper is to highlight the general aspects of the submission of a scientific manuscript, those that are often faced by young and experienced researchers. It is true that a formal training for a scientific career does not exist, the courses taught in the graduate programs are not sufficient to know the process to publish scientific papers. A manuscript evaluation by an editor is based on the recommendations from reviewers, therefore we consider important the knowledge for preparation of a letter of submission, how to respond to publishers and/or reviewers and all the additional knowledge necessary to register a paper to a scientific journal.