No abstract

No abstract

No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Blood platelets play a critical role in initiating thrombus formation and contribute to cardiovascular disorders-most commonly, coronary artery disease-by causing angina pectoris and myocardial infarction (1). Thromboxane A2 (TXA2), a metabolite of arachidonic acid (Fig. 1), is a potent physiological stimulant for platelets and vascular smooth muscle (2) and can promote myocardial ischemic damage by inducing platelet microthrombi. Sulotroban (Fig. 2) is an antithrombotic drug that prevents the fixation of TXA2 on its binding sites (3). We describe below a new method for the preparation of this substance. This experiment is an attractive training exercise for students who enter medicinal chemistry.