Introduction and Objective.Periodontal disease is one of the many diseases of the oral cavit. Periodontium is defined as the tissues that surround and hold the tooth in the socket. Periodontitis may lead to the loss of hard and soft tissues, resulting in the loss of dentition. The current standards for the treatment of periodontal disease are based on both surgical treatment and non-surgical treatment. The subject of research among many scientists is the effect of flavonoids -substances of plant origin, on periodontal diseases. This literature review aims to present the possibility of using flavonoids as adjunctive treatment in periodontal diseases. Review Methods. Articles in English were searched using PubMed databases to evaluate the effect of flavonoids in the prevention and treatment of periodontal disease. The bibliography was reviewed to eliminate duplicate works. Brief description of the state of knowledge. The anti-inflammatory, antibacterial and antiresorptive properties of flavonoids are the main factors influencing their use in the prevention of periodontal disease. Thanks to these three properties, the risk of periodontal disease is significantly reduced, which is why extracts from plants with a high flavonoid content are increasingly used in products for daily oral hygiene. Summary. The antibacterial, anti-inflammatory and antiresorptive effects of flavonoids make them an important factor in the treatment of periodontal disease. Further research in the use of natural medicinal substances of plant origin is an important aspect for the development of modern medicine.