INTRODUCTION:The use of platelet concentrates is recent and its efficiency remains controversial. The mineralized plasmatic matrix (MPM), is the latest innovation of platelet concentrates (i.e. PRP and PRF). A new concept of fabricating growth factors-enriched bone graft matrix has been introduced since 2010. It utilizes altering the centrifugation speed and time to produce much larger, denser and richer fibrin matrix containing growth factors, known as Sticky bone. MPM combines the best of both worlds; its mineral phase qualifies it as an osteoconductive scaffold for bone formation while its platelet concentrate phase grants it an osteoinductive property by the slow release of growth factors. OBJECTIVES: To evaluate the effectiveness of using MPM, compared to the use of bone graft alone, to assess the exact effect of each in enhancing the osteogenic differentiation and bone formation.