Information derived from pharmaceutical marketing databases on the use of 12 nonsteroidal antiinflammatory drugs in 1983 is presented. Estimates of population exposure, regularity of treatment, average daily dose, age and sex distributions of users, concomitant use of other drugs, associated diagnoses, and trends in use are provided. Utilization patterns were similar for 8 of the nonsteroidal antiinflammatory drugs, with differing patterns seen for mefenamic acid, oxyphenbutazone, phenylbutazone, and zomepirac.

The configuration of nonachlor, mp 128- 130°C, was elucidated, from both the structure of its dehydrochlorinated product and the synthesis of stereoisomeric nonachlor, as possessing a l-exo,2-endo,3-exo (i.e., trans-nonachlor) chlorine arrangement in the cyclopentane ring. Dehydrochlorination of transnonachlor yields 1,2-dichlorochlordene, the structure of which was established by specific allylic dechlorination to 2-chlorochlordene. Further confirmation was obtained by conversion to l-keto-2-chlorochlordene. An alternative synthesis of this chloroketone from 1-ketochlordene is described. An isomeric nonachlor, mp 214-215°C, with the l-exo,2-exo, 3-exo (i.e., cis-nonachlor) chlorine arrangement was prepared from a heptachlor chlorohydrin of known configuration. Dehydrochlorination of cis-nonachlor gave 1,3-dichlorochlordene. The reactions of these 2 nonachlors with base is discussed with reference to cisand trans-chlordane.

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