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Objective. This study sought to measure the ability and receptiveness of medical students for creating evidence-based edits in Wikipedia for learning components of evidence-based practice. Methods. Senior medical school students in an elective in clinical informatics and evidencebased medicine during 2007 (n=21) or 2008 (n=18) were taught how to place succinct summaries of studies in Wikipedia. Online help was provided. In 2008, an online template facilitated editing. Results. Combining the two years, all students but one (97%) cited articles in PubMed and 85% created links to abstracts in PubMed. Most students (79%) reported a study design and 72% provided numeric results. In 2007, 14% of students created complete citations, compared to 78% in the second year (p < 0.05). At two months follow-up, 44% of students had at least one edit improved and one edit from 2007 was deleted. In 2007, 83% (15/18) of the students agreed or strongly agreed that the exercise should be offered to the next year's class. In 2008, this rate was 100% (16 respondents). Conclusions. Among these self-selected students, most students were positive about the assignment and almost all created edits that succinctly summarized research results and attributed evidence.

SYNOPSISThe synthesis of various phosphoranimines including ( CH30CHzCHz0 ) ( CFBCH20 )2PCH3)3 via the Staudinger reaction of ( CH3)3SiN3 with the suitably substituted phosphite is reported. These monomers were polymerized using tetra-n-butylammonium fluoride and N-methylimidazole in various solvents at several temperatures. I n sku 31P-NMR kinetic studies and M , versus time studies were also performed for the monomers to understand the propagation mechanism.

The single enantiomers of 2-naphthylalanine and N-tert-butoxycarbonyl 2-naphthylalanine were prepared from 2-naphthaldehyde. The sequence has been optimized and run on multikilogram scale, with the key step the asymmetric hydrogenation of methyl 2-acetamido-3-(2-naphthyl)propenoate using the rhodium complex of the methyl BoPhoz ligand, which proceeded smoothly at scale with 97.9% ee. Enhancement to >99.5% ee was achieved by crystallization of the methyl 2-amino-3-(2-naphthyl)propanoate methanesulfonic acid addition salt, the product of acidic deacylation of the hydrogenation product. This protocol for enantiomeric purity enhancement appears to be general for these types of amino acid derivatives. Subsequent transformations did not effect the enantiomeric purity, affording the desired products in >99.5% ee.