Acceptance and Commitment Therapy (ACT) is one of the methods of improving the quality of life and enhancing psychosocial flexibility in students with learning disorders. Objectives: The aim of this study was to determine the effectiveness of ACT on the quality of life and psychological flexibility of female junior high school students with learning disorders in Sari, Iran. Materials and Methods: The present quasi-experimental study used a Pre-test-Post-test design with a control group. The statistical population consisted of all female junior high school students in Sari. A total of 60 individuals were selected by convenience sampling method and were randomly assigned to the experimental and control groups. The intervention was performed for the experimental group. The 36-item short form health survey and cognitive flexibility inventory were used to collect the data. The data were analyzed by analysis of covariance, using SPSS version 21. Results: The ACT had significant effects on the psychosocial flexibility and quality of life of female junior high school students with learning disorders (P<0.001). Conclusion: The ACT improved the quality of life and psychological flexibility of female junior high school students with learning disorders.

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