Objectives: Miscarriage is defined as the loss of pregnancy before the 20 weeks of gestational age. This study was conducted to compare the induction abortion in the first trimester using misoprostol alone and misoprostol with estrogen priming. Materials and Methods: This clinical trial was conducted in Ali ibn-e Abitalib hospital of Zahedan in 2017. A total of 100 women with missed abortions under 14 weeks of gestational age were evaluated. The women were randomly assigned into the misoprostol alone and misoprostol with estrogen priming groups. Ultrasound was done to evaluate the presence of remnants 4 hours after the abortion. If it was less than 10 mm, the abortion was considered successful. Results: The success rate was 38% in the misoprostol group and 86% in the misoprostol with estrogen priming group. Conclusions: Overall, this study showed that estrogen increases the success rate of abortion and reduces the time to abortion.