Isolated acquired factor VII deficiency is a rare coagulopathy. It has been reported in 31 patients with malignancy, sepsis, postoperatively, aplastic anemia, and during bone marrow transplantation. We discuss, through a new case of acquired factor VII deficiency, the characteristics of this disease when it is associated with acute myeloid leukemia. Acquired factor VII deficiency in hematological diseases can be caused by intensive chemotherapy, infections, or hepatic dysfunction. The best treatment in developing countries remains corticosteroids associated with plasma exchange, frozen plasma, and antibiotics.

We report the case of a 40-year-old male presented with a painless right testicular swelling. Right radical orchidectomy was performed. The pathological diagnosis was peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). According to Ann Arbor staging, the initial clinical stage was IEa. Treating him with four courses of the CHOEP protocol and intrathecal prophylactic chemotherapy was unsuccessful; with the appearance of orbital infiltration and a loco-regional extension. Although the patient started a second line chemotherapy, he unfortunately succumbed to death.

Primary splenic non-Hodgkin lymphoma is extremely rare, characterized by isolated splenic disease without other lymphoma locations. It’s most often revealed by isolated splenomegaly. We report the case of a 43-year-old female patient with an isolated massive splenomegaly. The etiological investigations were normal, however the diagnostic and therapeutic splenectomy was performed and revealed a diffuse large B-cell non-Hodgkin’s lymphoma. The patient received a post-splenectomy chemotherapy that had a favorable outcome after two years of follow-up. Le lymphome non hodgkinien splénique primitif est une entité extrêmement rare rapportée dans la littérature. Il est caractérisé par une atteinte splénique isolée sans autres localisations lymphomateuses au diagnostic, d’où l’intérêt d’y penser quand elle est d’origine indéterminée. Nous rapportons le cas d’une patiente âgée de 4 ans présentant une volumineuse splénomégalie isolée, les investigations à visée étiologique sont normales, une splénectomie dans un but diagnostique et thérapeutique est réalisée, objectivant un lymphome non hodgkinien à grandes cellules B. Une chimiothérapie post splénectomie est administrée. L’évolution est favorable après 2 ans de recul.