Background Sharing research outputs with open science methods for different stakeholders causes better access to different studies to solve problems in diverse fields, which leads to equal access conditions to research resources, as well as greater scientific productivity. Therefore, the aim of this study was to perceive the concept of openness in research among Iranian health researchers. Methods From the beginning of August to the middle of November 2021, twenty semi-structured interviews were held with Iranian health researchers from different fields using purposeful, snowball, and convenience sampling. The interviews continued until data saturation. Data analysis was performed with thematic analysis using MAXQDA 20. Finally, seven main issues related to open science were identified. Results Through analysis of the interviews, 235 primary codes and 173 main codes were extracted in 22 subclasses. After careful evaluation and integration of subclasses and classes, they were finally classified into nine categories and three main themes. Analysis showed that openness in research was related to three main themes: researchers’ understanding of open science, the impact of open science on publication and sharing of research, concerns and reluctance to open research. Conclusion The conditions of access to research output should be specified given the diversity of studies conducted in the field of health; issues like privacy as an important topic of access to data and information in the health system should also be specified. Our analysis indicated that the conditions of publication and sharing of research processes should be stated according to different scopes of health fields. The concept of open science was related to access to findings and other research items regardless of cost, political, social, or racial barriers, which could create collective wisdom in the development of knowledge. The process of publication and sharing of research related to open access applies to all types of outputs, conditions of access, increasing trust in research, creation of diverse publication paths, and broader participation of citizens in research. Open science practices should be promoted to increase the circulation and exploitation rates of knowledge while adjusting and respecting the limits of privacy, intellectual property and national security rights of countries.

The aim of this study was to conduct a comprehensive literature review of the dimensions of open science in research processes. A total of four databases and snowball searching were used for the comprehensive literature review during 2011–2020; then, we were able to find 98 studies based on the inclusion criteria. Also, we used thematic method to review the relevant studies and identified three categories of dimensions in the research process, namely (1) the publication and sharing category including open access, open data, transparency and reproducibility, citizen science, and crowd sourcing; (2) the infrastructure and cultural category including open infrastructure, open education, open tools, budget mechanism, open culture, and communication; and (3) governance and evaluation including policies, governance, and the ethical principles associated with open science. Open science emphasizes the efforts to open and make the scientific research process more inclusive so as to engage the inside and outside actors in the research process.