Addition of anti-thymocyte globulin in allogeneic stem cell transplantation with peripheral stem cells from matched unrelated donors improves graft-versushost disease and relapse free survival,

A B S T R A C TThe effect of CD34 + cell dose in allogeneic hematopoietic stem cell transplantation (HSCT) on overall survival (OS) and incidence of acute and chronic graft-versus-host disease (GvHD) has not been established and few studies have been performed. Our single center analysis included 189 patients with hematological malignancies who received peripheral blood stem cell (PBSC) grafts from sibling donors. Myeloablative conditioning was used in 88 cases and 101 received reduced intensity conditioning. The median CD34 + cell dose was 5.6 × 10 6 /kg (0.6-17.0). In the multivariate analysis, a CD34 cell dose of 6-7 × 10 6 /kg was associated with better OS and lower transplant-related mortality (TRM), while a dose of <5 × 10 6 /kg led to increased relapse and reduced chronic GVHD (cGVHD). A high CD34 cell-dose (>6.5 × 10 6 /kg) correlated with less acute GVHD (aGVHD) II-IV. We conclude that the CD34 cell dose has an impact on the outcome of HSCT from sibling donor PBSCs.

Abstract-The purpose of this paper is to investigate the relationship between National Culture (NC) and Organisational Culture (OC) in the context of private sector organisations in Iran. This paper outlines some frameworks of NC and OC then looks at some relevant specific cultural perceptions on the part of Iranian managers. The NC and OC of several organizations in Iran were investigated using survey methodology. Questionnaires were distributed through organisations either by email or hard copy. 221 questionnaires were returned. To investigate NC the researcher used the Dorfman and Howell questionnaire. Furthermore, to study OC the researcher used the Organisational Culture Assessment Instrument (OCAI) which is based on the CVF framework. Regression analysis of the results showed that most of the dimensions of NC have insignificant relationship with OC except for the relationship of NC with clan culture. However, the correlations analyses provide some additional support for the association between these two constructs. This paper concludes that company size can serve as an important and significant moderator of the association between NC and OC within these data. Moreover, the results indicate that both education and position serve as significant controls of the association between NC and OC. It is recommended that researchers should consider the industrial cultural effect as a factor that would help for a better understanding of the relationship between NC and OC phenomena.

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