Previous studies showed that Whole Body Vibration (WBV) is an effective modality for strength and power. WBV has many usages in training and rehabilitation. Core muscles have the central role in the stability of the spine and our daily activity; so, strengthening core muscles is essential. This study aimed to investigate the immediate effect of WBV on strength, endurance, and performance of core muscles in young, healthy females. Materials and Methods: This study was a quasi-experimental interventional study. Twelve young, healthy females (18-28 years old) participated in this study; they received WBV in semi-squat position 5 times in 60 seconds separated by 30-second rest. The parameters of WBV included the frequency of 30Hz and an amplitude of 4mm. The tests used for the evaluation of core stability included Vertical Jump (VJ), pressure biofeedback, front abdominal power, trunk extensor endurance, and trunk flexor endurance tests. The tests were performed before, immediately after, and 30 minutes after the intervention. Results: According to the results, the trunk extensor endurance test, front abdominal power test, and pressure biofeedback had a significant effect (P<0.05). However, no change was observed in the trunk flexor endurance test and VJ test (P>0.05). Conclusion: This study indicated that WBV could be useful in core stability, specifically for trunk extensor endurance, lumbar strength, and front abdominal power. More studies are required to prove the effect of WBV on VJ and trunk flexor endurance.