Purpose: This study aimed to estimate the agreement of astigmatism between an autorefractor (Topcon), cycloplegic refraction, subjective manifest refraction, front and back corneal astigmatism. Moreover, this study aimed to investigate which factors influence the difference between cycloplegic refraction and subjective manifest refraction in these keratonic eyes.Methods: subjective manifest refraction, Autorefractmeter were measured in 64 keratonic eyes of 43 patients (21-45 years old) before and after using cycloplegic drop. We measured Corneal values by using Scheimpflug tomography. Astigmatic power was converted to vectors. The agreement of astigmatism between an autorefractor (Topcon), cycloplegic refraction, subjective manifest refraction, front and back corneal astigmatism was measured overall and in each vector. The difference between Cycloplegic refraction and subjective manifest refraction was calculated in each vector axis. Factors were anticipated associated with discrepancy by using Multivariable Regression Analysis.Results: The maximum estimations of agreement were found berween autorefratometer and subjective manifest refraction in cylindrical power(Icc:0.703,P<0.026), cylindrical axis(Icc:0.943,P<0.0001) and astigmatic vestors of J0 (Icc:0.972,P<0.0001) and J45( Icc:827,P=0.006). The significant factors Associated With discrepancy between cyclorefraction and subjective manifest refraction in both vectors(J0 and J45) were Q-value(B Coefficient= -4.91, P<0.0001) (B Coefficient=1.01, P<0.0001), corneal astigmatism(B Coefficient= 0.66, P=0.001) (B Coefficient=0.11, P=0.001), Kmax(B Coefficient= -0.52, P<0.0001) (B Coefficient=0.07, P=0.02), IHA(B Coefficient=0.04, P=0.005) (B Coefficient= -0.03, P<0.0001). The significant associated factors for axis changes between cycloplegic refraction and subjective manifest refraction were cone location (B Coefficient= -33.34, P=0.001) and corneal astigmatism(B Coefficient= -0.1, P=0.04).Conclusion: Maximum agreement of subjective manifest refraction astigmatism is with auto refractometer in keratoconus patients, so it could be said that the result of the auto refractometer is the most appropriate starting point during subjective refraction in these patients. It can be predicted that the closer the keratoconus cone location relative to the center of the cornea and the lower the keratoconus patient's corneal astigmatism, the more the probability of axis changes by cycloplegic drop.