Neutral metal−benzene complexes, M
n
(benzene)
m
(M = Sc to Cu), are produced for all of
the 3d transition metals in the gas phase by using the laser vaporization method. These
species are characterized by mass spectrometry, photoionization spectroscopy, and chemical
probe experiments. Depending on the metal, there are two types of structures for
M
n
(benzene)
m
: multiple-decker sandwich structures and metal clusters fully covered with
benzene molecules (rice-ball structures). The former sandwich structure is characteristic of
the complexes for early transition metals (Sc−V), whereas the latter is formed for late
transition metals (Fe−Ni). Electronic structures of M1(benzene)
x
(x = 1, 2) complexes are
investigated through systematic measurements of ionization energies (E
i's).
This scoring system predicted cancer-specific survival in patients who did not meet the curative criteria after ESD for EGC. ESD without additional treatment may be an acceptable option for patients at low risk.
Diffuse large B-cell lymphoma (DLBCL) having both t(14;18) and 8q24 translocations is rare. We evaluated the clinical characteristics and prognoses of patients with DLBCL carrying both t(14;18) and 8q24 translocations. A total of 1972 patients with non-Hodgkin's lymphoma were treated in the Adult Lymphoma Treatment Study Group (ALTSG) from 1998 to 2007. Nineteen cases of de novo DLBCL with the dual translocation were identified. The dual translocation was observed in 19 of 394 patients with DLBCL (10 males and 9 females, with a median age of 61 years). The dual translocation was observed significantly more frequently among patients with high lactate dehydrogenase levels, B symptoms, bone marrow involvement and advanced stage. Immunophenotyping was performed and showed DLBCL with a germinal center type in the majority of cases. Progression-free survival and overall survival rates were significantly lower in patients with the dual translocation than in those with other translocation. DLBCL patients with concurrent t(14;18) and 8q24 translocations have very poor prognosis. Even if patients had a complete response to chemotherapy, they subsequently suffered early relapse. In this study, only a few patients received rituximab, and its usefulness could not be assessed. Future studies with larger numbers of patients are required.
This multi-center study, representing the largest cohort to date, revealed a large discrepancy between OS and DSS in the two groups. Since follow-up with no additional treatment after ESD may be an acceptable option for patients at low risk, further risk stratification is needed for appropriate individualized treatment strategies.
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