Plasminogen activator inhibitor (PAI) purified from human epidermis ) FEBS Lett. 408, 273-2771 was immunologically identified as placental-type PAI-2. In both fibrinolytic and synthetic substrate assays inhibitory activity of epiderma1 PA1 was neutralized by anti-PAI-2, but not by anti-endothelial type PAI-1. Immunoblotting technique confirmed that the purified epidermal PA1 is reactive with anti-PAI-2, but not with anti-PAI-1. Consequently PA1 in human epidermis was demonstrable by immunohistochemical technique.Placental-type plasminogen activator inhibitor-2; Endothelial-type plasminogen activator inhibitor-l; Urokinase; Tissue-type plasminogen activator; (Human epidermis)

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