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1 The effects of three analogues of N0-nitro-L-arginine (L-NOARG) and N0-monomethyl-L-arginine (L-NMMA), inhibitors of nitric oxide (NO) synthase, on hydrogen peroxide (H202)-induced endothelial cell injury were studied. 2 Endothelial cell injury was assessed by measuring the release of intracellular lactate dehydrogenase (LDH) and 5'Cr.3 Addition of H202 (250-1,000 pM) to endothelial cells induced the release of LDH dose-dependently.The release of LDH was reduced by pretreatment with N0-nitro-L-arginine methyl ester (L-NAME,

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