A large-scale isolation of the constituents of the cashew shell oil (Anacardium occidentale) was performed by medium-pressure liquid chromatography. A series of 12 components was isolated, including derivatives of anacardic acid, cardol, 2-methylcardol, and cardanol that differ in their side chain. These were tested against Biomphalaria glabratus, one of the snail vectors of schistosomiasis, and their structure-activity relationship is discussed. The principal components in the shell oil, nuts, and fruit juice were also quantitatively determined by high-performance liquid chromatography.

No abstract

Two new condensed guaiazulenoid pigments, gorgiabisazulene and gorgiagallylazulene, have been isolated from a gorgonian Acalycigorgia sp. and their structures have been established on the basis of spectroscopic and chemical evidence.

Eckol, 2-phloroeckol and dieckol, novel phlorotannins with a dibenzo-p-dioxin skeleton have been isolated from the brown alga Ecklonia kurome Okamura as plasma α2-macroglobulin inhibitors and their structures have been determined on the basis of spectral data, in particular, by means of negative NOEs.

Four new bioactive polyacetylenes have been isolated from the marine sponge Petrosia sp. Their structures including absolute stereochemistry have been elucidated by spectral and chemical methods.