In the physiotherapy, adequate exercise therapy has been important including aerobic and resistance exercise. Authors and colleagues have treated lots of patients with metabolic syndrome (Met-S) and reported for nutritional and exercise therapy. In this study, subjects included 73 patients with type 2 diabetes mellitus (T2DM) aged 66.8 ± 13.0 y.o. Methods included squat exercising 5 minutes twice a day for 6 months, using exercise equipment 'HiSquat'.The basal data were BMI 24.8 ± 4.8 kg/m 2 , abdominal circumference 87.2 ± 11.0 cm, thigh circumference 42.7 ± 6.2 cm, HbA1c 7.0 ± 1.0%. HbA1c value at 6 months was 6.5 ± 1.0%, with significant decrease. Significant correlation was shown between BMI and the abdomen/height ratio. Patients with higher HbA1c would be more effective for squat exercise therapy. There is limitation of this study, and further investigation of correlation among biomarkers would develop various researches. Our results would be fundamental and reference data in this research field.