Two cases of hard metal lung disease and pathological findings of giant cell interstitial pneumonia are reported. The cases worked in different factories manufacturing hard metal parts from tungsten carbide and cobalt. Pathological specimens were obtained by percutaneous thoracoscopy and transbronchial lung biopsy. X-ray microanalysis detected only tungsten carbide in the lung specimen of one case. Bronchoalveolar lavage showed diagnostic bizarre macrophages in the lavage fluid.

Experimental acute bacterial prostatitis in rats was induced by four different routes of bacterial inoculation. The most simple and reproducible method of producing bacterial prostatitis was to instil the bacterial suspension into the prostatic urethra after the administration of an appropriate antibiotic to prevent associated pyelonephritis.

The efficacy and safety of oral of loxacin, 400 mg once daily, for the treatment of patients with lower respiratory tract infections were studied. The most common species recovered from the sputum specimens of these patients were Haemophilus influenzae, followed by Streptococcus pneumoniae (S.pneumoniae), Staphylococcus aureus (S. aureus), Gram positive cocci unidentified, Pseudomonas aeruginosa (P. aeruginosa), Morexella catarrhalis, Streptococcus epidermidis, and another Haemophilus species in this order. All these bacteria were susceptible to of loxacin except for one strain of methicillin resistant S. aureus. A satisfactory clinical outcome was achieved in 34 of 40 patients (85%). It is concluded that of loxacin, 400 mg once daily, is useful for patients with respiratory tract infections.

Two spiro[1,2-dioxetane-3,6'-benzo(c)chromene]s bearing a t-butyldimethylsiloxy as a trigger at the 10'- or 2'-position were synthesized. On treatment with tetrabutylammonium fluoride in DMSO at 25 degrees C, the 10'-siloxyspiro[1,2-dioxetane-3, 6'-benzo(c)chromene] decomposed rapidly to afford a flash of blue light. The CIEEL decay of this spirochromenedioxetane was also induced by basic silica gel in hexane. By contrast, TBAF-induced decomposition of an analogous spiro[1,2-dioxetane-3, 6'-benzo(c)chromene] with a trigger at the 2'-position, resulted in emission of yellow light with very low efficiency.