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A stable form of vitamin C, L-ascorbyl-2-phosphate-Mg (APM), was tested for efficacy as a vitamin C source in the juvenile yellowtail Seriola quinqueradiata. The fish, weighing 2.67g, were fed 4 fish meal-based diets containing graded levels of supplemental APM (0, 3, 6, and 10mg/100g diet) for 83 days. The fish receiving the diet without supplemental APM showed deficiency symptoms such as reduced growth rate, deformity (lordosis and scoliosis), distorted gill support cartilage (degeneration of the ravine part of gill-cover), high mortality, and so on. The supplementation of 3 to 10mg of APM/100g diet improved the growth and feed efficiency of the fish. The results of the feeding experiment indicated that a supplement of about 3 to 6mg APM/100g diet was sufficient to support good growth and survival and to prevent the gross vitamin C deficiency symptoms of the yellowtail. The supplementation of APM elevated the L-ascorbic acid (AsA) contents of serum and liver, serum alkaline phosphatase activity, and the ratio of hydroxyproline/ proline in the bone. The results of the present study showed that APM can be effectively utilized by the yellowtail as a good replacement for AsA.Since L-ascorbic acid (AsA) is a water-soluble, thermolabile vitamin, and is easily oxidized to an inactive form, it is considerably decreased during diet processing, storage, and exposure to sea water due to exidation and leaching in water

ABSTRACT-Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one), a newly synthesized cognitive enhancer, and donepezil and tacrine on the scopolamine-induced cognitive deficits in rats were examined in passive avoidance and radial-arm maze tasks. ZSET845 (0.01 mg/kg) showed a greater ameliorative effect than donepezil (0.1 mg/kg) or tacrine (1 mg/kg) in the passive avoidance task. In the radial-arm maze task, ZSET845 (0.1 mg/ kg) also showed a greater effect than donepezil (10 mg/kg) or tacrine (10 mg/ kg). ZSET845 induced an increase in the choline acetyltransferase (ChAT) activity in the hippocampus, suggesting that the ameliorative effects of ZSET845 are related to the increase in the ChAT activity in the hippocampus.

A 67-year-old man who had a history of syncope was admitted because of effort angina. The sinus node (SN) was the single blood supply from the right coronary artery (RCA). After we implanted 2 everolimus-eluting stents for RCA, slow-flow occurred and the SN artery was occluded, and junctional escape rhythm was sustained. After the wiring to the occluded SN artery, junctional escape rhythm immediately recovered to sinus rhythm, and the patient achieved continuous sinus rhythm and stable hemodynamics. Given that acute SN ischemia is a possible cause of sinus dysfunction, careful choice of a percutaneous coronary intervention strategy should be taken into consideration if the SN artery is the single blood supply from the RCA and if syncopal history is present.

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