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Plasma cyclic AMP concentration after glucagon injection intravenously was determined in 8 normal subjects, 15 patients with liver cirrhosis, 10 patients with chronic hepatitis, and 8 patients with acute hepatitis.Plasma fasting cyclic AMP indicated comparatively high in patients with chronic hepatitis and hepatoma, compared with normal subjects.Plasma cyclic AMP levels at 10 minute after glucagon injection were maximum, and peak values of cyclic AMP in acute hepatitis or chronic hepatitis were significantly higher than those in normal subjects, but those in decompensated cirrhosis were lower than those in normal subjects.